Retroviruses encode a small, basic nucleocapsid (NC) protein that is found complexed to genomic RNA within the viral particle. The NC protein appears to function not only in a histone‐like manner in packaging the RNA into the particle but also in specifically selecting the viral genomic RNA for packaging. A cysteine‐histidine (cys‐his) region, usually composed of 14 amino acids and reminiscent of the ‘zinc fingers’ of transcription factors, is the only highly conserved sequence element among the retroviral NC proteins. This (...) review discusses the biochemical properties of NC, and its possible role(s) in retroviral replication. We also speculate on how the biochemical properties may relate to its function in RNA recognition and packaging. (shrink)

In the aftermath of the events of September 11, 2001, Stanley Katz (who now chairs the editorial board of this journal) invited the intellectual community to reflect on its own history of involvement in public affairs and to make good on its mistakes. This essay examines a single case of intellectuals involving themselves in public affairs and some of the difficulties in saying and evaluating exactly what happened. Critical attention is given to Anthropological Intelligence, a book by David Price (...) published in 2008, which concerns the involvement of anthropologists in wartime activities during World War II and argues that even that “just war” left an indelible stain on the moral fabric of the discipline. (shrink)

Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.

Humanist sociologists are activists rooted in the reality of history and change and guided by a concern for the 'real life' problems of equality, peace, and social justice. They view people as active shapers of social life, capable of creating societies in which everyone's potential can unfold. Alfred McClung Lee introduces this volume with 'Sociology: Humanist and Scientific' and develops the theme that a sociology that is humanist is also scientific. The other nine selections are grouped into four parts: 'The (...) Individual and Social Life;' 'Social Institutions: Technology, Science, and Formal Organization;' 'Political Structures: Issues of Justice and Equality;' and 'Methodological Critiques and Counterproposals.'. (shrink)

The essays in this volume are a contribution to this process of reappraisal, focusing specifically on the phenomena of scepticism and millenarianism, especially ...

Misuse or misunderstanding of medication information is a common and costly problem in the U.S. The risks of misunderstanding medication information are compounded for the large and growing population of individuals with limited English proficiency that often lacks access to this information in their own language. This paper examines practices related to translation of medication information in the European Union that may serve as a model for future U.S. policy efforts to improve the quality and availability of medication information for (...) individuals with limited English proficiency. (shrink)

Access to clear and concise medication information is essential to support safe and effective use of prescription drugs. Patient misunderstanding of medication information is a common reason for non-adherence to medication regimens and a leading cause of outpatient medication errors and adverse drug events in the U.S. Medication errors are the most common source of risk to patient safety, leading to poor health outcomes, hospitalizations, and deaths. Over half a million adverse drug events occur in the outpatient setting each year (...) at a cost of approximately $1 billion annually.Nearly half of adults in the U.S. experience difficulty understanding and acting upon health information. Even individuals with high levels of general literacy may find medication information difficult to understand or use. The risk of misunderstanding medication information is compounded for patients with limited English proficiency who may not have access to this information in their own language. (shrink)

In the late 1970s and early 1980s, Richard Rorty advocated that his confréres kick the ‘philosophy habit’-that is, adopt a post-positivist, post-metaphysical style of interpretation. Philosophers largely ignored Rorty’s clarion call. Unburdened by the kind of Selbstverständnis of scholarly mission held by most analytics, members of departments of literature instead became the most important advocates for reading literature philosophically during the last two decades of the twentieth century. Though the academic Left, especially practitioners of ‘theory’, largely celebrated and encouraged (...) this development, Rorty, in the late 1990s, came to view it as harmfully elevating ‘cultural politics’ above ‘real politics’, which would ultimately lead to the abandonment of civic responsibilities. While heavy-handed and partial, Rorty’s critique of the uses of philosophy by literary critics was not only perceptive, but can be helpful for understanding how the contemporary academic Left might move forward as well. (shrink)

To reject a false theory on the basis of an unsound argument is, in my opinion, as much an intellectual sin as to embrace a false theory. Thus, although I am no fan of any particular form of moral rationalism—and, indeed, on occasion have gone out of my way to criticize it—when rationalism is assailed for faulty reasons I find myself in the curious position of leaping to its defense (which goes to show that in philosophy it isn’t the case (...) that one’s enemy’s enemy is one’s friend). This puts me at something of a dialectical disadvantage, since my “defense” of moral rationalism has strict limits: I will defend it against specific kinds of criticism, but I have no interest in defending it simpliciter. It is important to bear in mind that what is in dispute between Shaun Nichols and myself is not the truth or falsity of moral rationalism, but rather what kind of evidence bears on the matter. (shrink)

How much can and should be said about the beginning of Wittgenstein's Philosophical Investigations (PI) on the basis of its very first section alone? Is the only thing worth mentioning that it is designed to introduce the topic for the rest of the book - may this be a "pre-philosophical", "pre-theoretical", "Augustinian" picture of Ianguage (Baker/Hacker, Kenny, Katz, Canfield et al.) or a mentalistic picture of the use of language (Savigny)? These ways of interpreting leave too many aspects of (...) the text untouched. Some of these are: Why does Wittgenstein quote just from the Confessions if his only interest was to get a picture of language? How about Wittgenstein's different ways of dealing with the quotation from Augustine? Trying to answer these questions means to develop a new, more complicated picture o f the beginning of the PI. (shrink)

How much can and should be said about the beginning of Wittgenstein's Philosophical Investigations (PI) on the basis of its very first section alone? Is the only thing worth mentioning that it is designed to introduce the topic for the rest of the book - may this be a "pre-philosophical", "pre-theoretical", "Augustinian" picture of Ianguage (Baker/Hacker, Kenny, Katz, Canfield et al.) or a mentalistic picture of the use of language (Savigny)? These ways of interpreting leave too many aspects of (...) the text untouched. Some of these are: Why does Wittgenstein quote just from the Confessions if his only interest was to get a picture of language? How about Wittgenstein's different ways of dealing with the quotation from Augustine? Trying to answer these questions means to develop a new, more complicated picture o f the beginning of the PI. (shrink)

In patients with pain characterized by a painful focus and allodynia, the painful symptoms arise from altered central processing that is initiated and subsequently maintained by persistent input from nociceptive afferents. Treatments directed at this normal consequence of persistent input are inherently limited. The most efficacious treatments will target the pathology, the various sources of ongoing nociceptor input. [blumberg et al.; coderre & katz; dickenson].

Do other living creatures alienate themselves from their own species with only selfish concern for material successes and external achievement? ...

Because little is known about the human trait of affiliation, we provide a novel neurobehavioral model of affiliative bonding. Discussion is organized around processes of reward and memory formation that occur during approach and consummatory phases of affiliation. Appetitive and consummatory reward processes are mediated independently by the activity of the ventral tegmental area (VTA) dopamine (DA)–nucleus accumbens shell (NAS) pathway and the central corticolimbic projections of the u-opiate system of the medial basal arcuate nucleus, respectively, although these two projection (...) systems functionally interact across time. We next explicate the manner in which DA and glutamate interact in both the VTA and NAS to form incentive-encoded contextual memory ensembles that are predictive of reward derived from affiliative objects. Affiliative stimuli, in particular, are incorporated within contextual ensembles predictive of affiliative reward via: (a) the binding of affiliative stimuli in the rostral circuit of the medial extended amygdala and subsequent transmission to the NAS shell; (b) affiliative stimulus-induced opiate potentiation of DA processes in the VTA and NAS; and (c) permissive or facilitatory effects of gonadal steroids, oxytocin (in interaction with DA), and vasopressin on (i) sensory, perceptual, and attentional processing of affiliative stimuli and (ii) formation of social memories. Among these various processes, we propose that the capacity to experience affiliative reward via opiate functioning has a disproportionate weight in determining individual differences in affiliation. We delineate sources of these individual differences, and provide the first human data that support an association between opiate functioning and variation in trait affiliation. Key Words: affiliation corticolimbic-striatal networks; appetitive and consummatory reward; dopamine; oxytocin; personality; social bonds; social memory; u-opiates. (shrink)

The reputation and influence of Emmanuel Levinas has grown powerfully. Well known in France in his lifetime, he has since his death become widely regarded as a major European moral philosopher profoundly shaped by his Jewish background. A pupil of Husserl and Heidegger, Levinas pioneered new forms of exegesis with his post-modern readings of the Talmud, and as an ethicist brought together religious and non-religious, Jewish and non-Jewish traditions of contemporary thought. Richard A. Cohen has written a book which (...) uses Levinas' work as its base but goes on to explore broader questions of interpretation in the context of text-based ethical thinking. Levinas' reorientation of philosophy is considered in critical contrast to alternative contemporary approaches such as those found in modern science, psychology, Nietzsche, Freud, Husserl, Heidegger, Sartre, Merleau-Ponty, Derrida and Ricoeur. Cohen explores a manner of philosophizing which he terms 'ethical exegesis'. (shrink)

This elevating pull of an ethics that can account for the relation of self and other without reducing either term is the central theme of these essays.

This is one of the most important books on quantum mechanics to have appeared in recent years. It offers a dramatically new interpretation that resolves puzzles and paradoxes associated with the measurement problem and the behavior of coupled systems. A crucial feature of this interpretation is that a quantum mechanical measurement can be certain to have a particular outcome even when the observed system fails to have the property corresponding to that outcome just prior to the measurement interaction.

_Epistemology _is an accessible and indispensable volume for undergraduates studying philosophy. Essential introduction to epistemology, a field of fundamental philosophical importance Offers concise and well-written synopses of different epistemological debates and concerns.

The Ethics Program at General Dynamics was evaluated relative to its stated objectives and its implied objectives. The program was found to have met its specific objectives which require employees to follow rules and standards of conduct. The program did not apparently meet its implied objectives which would have created a more humanistic work environment for employees. This result apparently stemmed from program planners' intentions to use the hope for better working conditions as a motivation for employees to follow company (...) standards. A substantial conflict was found between the philosophical bases for ethics programs and work environment improvement programs. (shrink)

An introduction to the ethical and ontological import of Levinas' philosophy.

A Conversation with Claire Katz about her book, Levinas and the Crisis of Humanism.

... and Normative Epistemology The Distinction Between Metaepistemology and Normative Epistemology Although this terminology is relatively new, ...

Models of psychological time / Richard A. Block -- Implicit and explicit representations of time / John A. Michon -- The evasive art of subjective time...

The purpose of this research is to extend prior research testing the premise that small deviations from ethical behavior lead to even larger deviations from ethical behavior. This study examines the association between a person’s willingness to bribe a police officer to avoid being issued a speeding ticket with their views on inappropriate behavior of corporate executives. Our sample of 528 participants comes from Colombia (90), Ecuador (70), South Africa (131) and the United States (237). As part of our data (...) gathering, we controlled for social desirability response bias in the responses of the students who participated in our study. Our data indicate significant differences between the views of the students from Colombia, Ecuador, and South Africa when compared to the views of the students from the United States. The analysis indicates that, for all four dilemmas, the most significant variable was the belief about how ethical it was to pay a bribe to avoid a traffic ticket. In addition, in three of our four dilemmas, Paulhus’ Impression Management Subscale, which measures social desirability response bias, was the second most significant variable. Finally, in three of the four dilemmas, the students from Colombia, Ecuador and South Africa thought the actions described in the dilemmas were less ethical than the students from the United States. (shrink)

Extraversion has two central characteristics: (1) interpersonalengagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and (...) motivation) is closely associated with extraversion. Extraversion is accordingly based on positiveincentivemotivation. (shrink)

Being 'biblical' : contexts and starting points -- Jesus of Nazareth : great moral teacher or friend of sinners? -- Paul : follower or founder? -- Mark : suffering for the kingdom -- Matthew : being truly righteous -- Luke-Acts : a universal concern -- John : teaching the truth in love -- Apartheid : an ethical and generic challenge to reading the New Testament.

Cigarette smoke is by far the leading preventable cause of death and disease in the United States. It has been estimated to kill between 419,000 and 589,000 smokers and up to 65,000 non-smokers each year. This premier status is hardly a new development, having been true for most of the last century, and known to be true at least since the first Surgeon General’s Report in 1964.Why then are tobacco products exempt from any significant federal oversight or control? Why do (...) cigarette advertisements, pitched to young smokers and non-smokers, continue to be plastered on every available surface inside and outside many convenience stores and to adorn the pages of popular magazines? Why, decades since the makers of far less dangerous products began to be held accountable in tort law, was the first payment by a cigarette company on a products liability judgment not made until 2001? (shrink)

Cigarette smoke is by far the leading preventable cause of death and disease in the United States. It has been estimated to kill between 419,000 and 589,000 smokers and up to 65,000 non-smokers each year. This premier status is hardly a new development, having been true for most of the last century, and known to be true at least since the first Surgeon General’s Report in 1964.Why then are tobacco products exempt from any significant federal oversight or control? Why do (...) cigarette advertisements, pitched to young smokers and non-smokers, continue to be plastered on every available surface inside and outside many convenience stores and to adorn the pages of popular magazines? Why, decades since the makers of far less dangerous products began to be held accountable in tort law, was the first payment by a cigarette company on a products liability judgment not made until 2001? (shrink)

This paper examines the associations among social desirability response bias, cultural constructs and gender. The study includes the responses of 1537 students from 12 countries including Australia, Canada, China, Colombia, Ecuador, Hong Kong, Ireland, Japan, Nepal, South Africa, Spain, and the United States. The results of the analysis indicate that, on average, social desirability response bias decreases (increases) as a country’s Individualism (Uncertainty Avoidance) increases. The analysis also indicates that women scored significantly higher on Paulhus’ Image Management Subscale on an (...) overall basis and for seven of the 12 country comparisons. This research serves as a caution when considering the research findings of prior international survey-based ethics research that do not include a direct measure of social desirability response bias. For example, the finding that women score higher on Paulhus’ measure of social desirability response bias calls into question prior research that does not control for social desirability response bias indicating women are more ethically sensitive than men. (shrink)

This paper examines the associations among social desirability response bias, cultural constructs and gender. The study includes the responses of 1537 students from 12 countries including Australia, Canada, China, Colombia, Ecuador, Hong Kong, Ireland, Japan, Nepal, South Africa, Spain, and the United States. The results of the analysis indicate that, on average, social desirability response bias decreases as a country's Individualism increases. The analysis also indicates that women scored significantly higher on Paulhus' Image Management Subscale on an overall basis and (...) for seven of the 12 country comparisons. This research serves as a caution when considering the research findings of prior international survey-based ethics research that do not include a direct measure of social desirability response bias. For example, the finding that women score higher on Paulhus' measure of social desirability response bias calls into question prior research that does not control for social desirability response bias indicating women are more ethically sensitive than men. (shrink)

Detailed exposition of the nine layers of signification of human mortality according to Emmanuel Levinas's phenomenological and ethical account of the meaning and role of death for the embodied human subject and its relations to other persons. Critical contrast to Martin Heidegger's alternative and hitherto more influential phenomenological-ontological conception, elaborated in "Being and Time", of mortality as Dasein's anxious and revelatory being-toward-death.

Brosio (social foundations of education, Ball State U.) describes and analyzes a number of philosophies that can provide a solid framework for the construction of critical, democratic educational theory and practice. Theorists discussed include the classical Greek thinkers, Marx, Dewey, the existentialists, liberationists, Freire, politics of identity thinkers, and postmodernists. Annotation copyrighted by Book News, Inc., Portland, OR.